Welcome to Ebrahimkhani Lab for Synthetic Biology and Regenerative Medicine
We study principles of organ repair and regeneration and develop technologies to modulate those processes!
Our research combines mouse models with systems and synthetic biology-based approaches to elucidate cellular interaction networks in liver homeostasis, with an emphasis on investigating how cellular ecology within multiple cell populations during regenerative processes directs the fate of a tissue towards healthy regeneration or fibrogenic state. Our research is informed by findings from studies in mouse models and applies synthetic biology approaches to engineer better in vitro human tissue surrogates and extrapolate mouse data to human. We have developed complex human liver micro-physiological systems called "liver organoids" in a dish and through recapitulation of morphogenetic processes in human iPSCs. We are studying the dynamic process of tissue development using our developed 3D vascularized liver organoids. Our vision is to advance liver therapeutics through systems and synthetic biology.
Learn more about the lab by exploring the website through the pictures below