Welcome to Ebrahimkhani Lab for Synthetic Biology and Regenerative Medicine
We study principles of morphogenesis and develop technologies to modulate those processes. Our research combines systems and synthetic biology-based approaches to elucidate cellular interaction networks during tissue development and regeneration. We examine how cellular ecology within multiple cell populations controls the fate of complex tissue. Our research is informed by findings from studies in mouse models and applies synthetic biology approaches to engineer better in vitro human tissue surrogates. Through genetic engineering of self-organization in human stem cells, we have developed complex multicellular systems and organoids. We are studying the dynamics of morphogenesis using our developed self-vascularized fetal liver tissues. Our vision is to advance regenerative medicine through integrating systems and synthetic biology.
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