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News:
December 2020- "Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids" is published in Cell Systems, showing that stem cells can be programmed, using genetic engineering, to grow into mature liver tissue; one that when transplanted into mice with liver disease can extend the lives of the sick animals. Read Mo's note in The Conversation on the background and summary of this research. Wisconsin Public Radio interviewed Mo about the overall process. UPMC and Pittsburgh Post-Gazette's reported the paper. The news found its way to the Italian newspaper Corriere Della Serra too. September 2020- "Synthetic immunomodulation with a CRISPR super-repressor in vivo" - a collaborative work with the Kiani Lab - is published in Nature Cell Biology, introducing an enhanced CRISPR-based transcriptional repressor to reprogram immune homeostasis in vivo. May 2020- Mo was selected as an awardee of Pitt's Pain Research Challenge 2020 for CRISPR-epigenetic therapeutics for pain management. May 2020- Jeremy & Ryan published their pre-print on genetic guided engineering of human liver organoids. January 2020- We published our paper on CRISPR-based synthetic TFs in Cell Systems. October 2019- Our labs moved to Pittsburgh Liver Center and Department of Pathology! July 2019- We got awarded an RO1 for developing a synthetic liver niche! with many exciting applications. Oct 2018- We got awarded a UO1 grant with Kiani lab to develop a multicellular liver platform on a chip for CRISPR testing. July 2018- We got awarded an RO1 together with Kiani lab at ASU to develop novel technologies for genetic circuit engineering with a set of applications in vivo. Read in Trends in Biotechnology our new paper about engineering morphogenesis! http://www.cell.com/trends/biotechnology/fulltext/S0167-7799(17)30301-3 Read in Cell Systems Voices : How we think about "Circuit Design", "Synthetic Biology" and "Encoding Collective Behavior"! |
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