Latest News
December 2021: Dr. Ebrahimkhani is one of the three Pitt researchers who have been awarded Charles E. Kaufman Foundation grants!
Click below to read more:
https://www.pitt.edu/pittwire/accolades-honors/three-pitt-researchers-earned-charles-e-kaufman-foundation-grants
https://kaufman.pittsburghfoundation.org/awards/initiative/2021/morphogenesis
Click below to read more:
https://www.pitt.edu/pittwire/accolades-honors/three-pitt-researchers-earned-charles-e-kaufman-foundation-grants
https://kaufman.pittsburghfoundation.org/awards/initiative/2021/morphogenesis
August 2021: We got awarded a NSF Grant together with the Kiani lab to work on "Directed Differentiation of Human Liver Organoids via Computational Analysis and Engineering of Gene Regulatory Networks", starting in 2022.
August 2021: Congratulations to Mohammad Naser Taheri on his Bioengineering Gerald McGinnis Graduate Fellowship in Innovative Medical Technologies Development!
July 2021: Our paper "Inferring cell-cell interactions from pseudotime ordering of scRNA-Seq data" is on BioRxiv.
Click here for the full article
Dongshunyi Li, Jeremy J. Velazquez, Jun Ding, Joshua Hislop, Mo R. Ebrahimkhani, Ziv Bar-Joseph
bioRxiv 2021.07.28.454054; doi: https://doi.org/10.1101/2021.07.28.454054
Click here for the full article
Dongshunyi Li, Jeremy J. Velazquez, Jun Ding, Joshua Hislop, Mo R. Ebrahimkhani, Ziv Bar-Joseph
bioRxiv 2021.07.28.454054; doi: https://doi.org/10.1101/2021.07.28.454054
May 2021: Dr. Mo Ebrahimkhani publishes manuscripts in iScience, Journal of Hepatology and transplant international
Dr. Mo Ebrahimkhani published an article in iScience entitled, "Synthetic living machines: A new window on life."
- Click here for the full article
Ebrahimkhani MR, Levin M. Synthetic living machines: A new window on life. iScience. 2021 May 4;24(5):102505. doi: 10.1016/j.isci.2021.102505. PMID: 34041452; PMCID: PMC8141884.
Dr. Ebrahimkhani published an editorial in the Journal of Hepatology, entitled, "Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins."
- Click here for the full article
Boulter L, Ebrahimkhani MR. Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins. J Hepatol. 2021 May 21:S0168-8278(21)00341-X. doi: 10.1016/j.jhep.2021.05.006. Epub ahead of print. PMID: 34029636.
Ebrahimkhani Lab published a paper in transplant international. The article, "Cholangiocyte Organoids as a Cell Source for Biliary Repair," can be found below. Jeremy Velazquez also contributed to this study.
- Click here for the full article
Velazquez JJ, Ebrahimkhani MR. Cholangiocyte Organoids as a Cell Source for Biliary Repair. Transpl Int. 2021 May 11. doi: 10.1111/tri.13902. Epub ahead of print. PMID: 33977592.
Dr. Mo Ebrahimkhani published an article in iScience entitled, "Synthetic living machines: A new window on life."
- Click here for the full article
Ebrahimkhani MR, Levin M. Synthetic living machines: A new window on life. iScience. 2021 May 4;24(5):102505. doi: 10.1016/j.isci.2021.102505. PMID: 34041452; PMCID: PMC8141884.
Dr. Ebrahimkhani published an editorial in the Journal of Hepatology, entitled, "Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins."
- Click here for the full article
Boulter L, Ebrahimkhani MR. Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins. J Hepatol. 2021 May 21:S0168-8278(21)00341-X. doi: 10.1016/j.jhep.2021.05.006. Epub ahead of print. PMID: 34029636.
Ebrahimkhani Lab published a paper in transplant international. The article, "Cholangiocyte Organoids as a Cell Source for Biliary Repair," can be found below. Jeremy Velazquez also contributed to this study.
- Click here for the full article
Velazquez JJ, Ebrahimkhani MR. Cholangiocyte Organoids as a Cell Source for Biliary Repair. Transpl Int. 2021 May 11. doi: 10.1111/tri.13902. Epub ahead of print. PMID: 33977592.
May 2021: Dr. Ebrahimkhani was interviewed on Science Rehashed Podcast. This interview, entitled, "A machine learning-enabled shortcut to engineer human liver organoids," is now airing on Spotify, Apple Podcast, and Google Podcast.
May 2021: The Pitt Med's 2021 Spring issue is published including a story about a collaborative project of Kiani Lab and Ebrahimkhani Lab regarding the application of CRISPR-Cas9 gene-therapy.
https://www.pittmed.health.pitt.edu/story/disparity-dashboard
https://www.pittmed.health.pitt.edu/story/disparity-dashboard
April 2021: Congratulations to Rayna Schoenberger for receiving funding in the Swanson School of Engineering Summer Undergraduate Research Internship (SURI) program. Rayna will work on her project “The Implementation of Landing Pad Sites in Human Induced Pluripotent Stem Cells” to be conducted under the mentorship of Dr. Ebrahimkhani.
January 2021: Neighborhood Impact Factor to Study Cell-Fate Decision-Making in Cellular Communities is published in Methods Mol Biol./Springer Protocols. Mo, Joshua and Jeremy were all involved in this study.
December 2020: Mo contributed to two publications: Human biomimetic liver microphysiology systems in drug development and precision medicine, published in Nat Rev Gastroenterol Hepatol, and Multicellular systems to translate somatic cell genome editors to humans, published in Current Opinion for Biomedical Engineering.
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December 2020: "Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids" is published in Cell Systems, showing that stem cells can be programmed, using genetic engineering, to grow into mature liver tissue; one that when transplanted into mice with liver disease can extend the lives of the sick animals.
Read Mo's note in The Conversation on the background and summary of this research. Wisconsin Public Radio interviewed Mo about the overall process of engineering stem cells to organoids and its potentials in organ regeneration. UPMC and Pittsburgh Post-Gazette's reported the paper. The news found its way to the Italian newspaper Corriere Della Serra too. |
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September 2020: "Synthetic immunomodulation with a CRISPR super-repressor in vivo" is published in Nature Cell Biology.
In a collaborative work between the Kiani Lab and the Ebrahimkhani Lab, we introduce an enhanced CRISPR-based transcriptional repressor to reprogram immune homeostasis in vivo.
Read Pitt Wire's story for the author's thoughts as well.
In a collaborative work between the Kiani Lab and the Ebrahimkhani Lab, we introduce an enhanced CRISPR-based transcriptional repressor to reprogram immune homeostasis in vivo.
Read Pitt Wire's story for the author's thoughts as well.
August 2020: Joshua and Ryan received CATER (the Cellular Approaches to Tissue Engineering and Regeneration) pre-doctoral fellowship awards supported by National Institute of Biomedical Imaging and Bioengineering (NIBIB) T32 program, University of Pittsburgh, and McGowan Institute for Regenerative Medicine, for 2 years and 1 year respectively.
May 2020: Mo was selected as an awardee of Pitt's Pain Research Challenge 2020 along with Dr Samira Kiani for their CRISPR-epigenetic therapeutics for pain management. https://ctsi.pitt.edu/funding/funding-opportunities/pain-research-challenge/pain-research-challenge-awardees/
May 2020: Jeremy & Ryan published their pre-print on genetic guided engineering of human liver organoids.
January 2020: All lab members settled at the University of Pittsburgh and started their benchwork.
January 2020: We published our paper on CRISPR-based synthetic TFs in vivo in Cell Systems.
October 2019: Our labs moved to Pittsburgh Liver Center and Department of Pathology!
July 2019: We got awarded an RO1 for developing a synthetic liver niches! with many exciting applications.
October 2018: We got awarded a UO1 grant with Kiani lab to develop a multicellular liver platform on a chip for CRISPR testing. https://commonfund.nih.gov/editing
July 2018: New paper through our collaboration! for more info see "An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods. 2018 Jul 16".
June 2018
Mo presented in Synthetic Biology Engineering Evolution Design SEED meeting 2018 on How to integrate synthetic biology with organoid engineering! SEED 2018 focused on advances in science, technology, applications, and related investments in the field of synthetic biology.
Mo presented in Synthetic Biology Engineering Evolution Design SEED meeting 2018 on How to integrate synthetic biology with organoid engineering! SEED 2018 focused on advances in science, technology, applications, and related investments in the field of synthetic biology.
June 2018
Congratulations to Jeremy and Ryan for presenting the lab at FASEB liver Meeting 2018. Two cool presentations on how we apply cellular engineering to direct tissue development.
Congratulations to Jeremy and Ryan for presenting the lab at FASEB liver Meeting 2018. Two cool presentations on how we apply cellular engineering to direct tissue development.
Spring 2018
We got awarded an RO1 together with the Kiani lab at ASU from NIH NIBIB to develop novel technologies for cell engineering, genetic circuit development and applications for in vivo.
can't wait to push this exciting collaboration :)
We got awarded an RO1 together with the Kiani lab at ASU from NIH NIBIB to develop novel technologies for cell engineering, genetic circuit development and applications for in vivo.
can't wait to push this exciting collaboration :)
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Dec 8, 2017: Our paper with Cahan lab is online now @TrendsinBiotech ! Thanks to everyone involved! It was fun and look forward to more papers to come!
Programming Morphogenesis through Systems and Synthetic Biology http://www.cell.com/trends/biotechnology/fulltext/S0167-7799(17)30301-3 |
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Oct 2017: Jeremy presented his studies in two meetings :
BMES 2017 Phoenix! http://www.bmes.org/annualmeeting and AASLD 2017 in Washington DC! www.aasld.org/events-professional-development/liver-meeting
BMES 2017 Phoenix! http://www.bmes.org/annualmeeting and AASLD 2017 in Washington DC! www.aasld.org/events-professional-development/liver-meeting
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Sep 2017: Our paper published in ACS Synth Biol: Engineered CRISPR Systems for Next Generation Gene Therapies.
Also We Got the Cover Art ! Congrats to our lab and also Kiani's lab ! |
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July 2017: Mo was appointed as an Adjunct Assistant Professor of Medicine at Mayo Clinic College of Medicine and Science.
May 25, 2017: Mo gave a talk in Mayo Clinic on " Stem Cell-derived Organoids: New Technologies to Advance Human Liver Biology and Medicine".
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May issue of Cell Systems 2017: Read in Cell Systems Voices : How we think about "Circuit Design", "Synthetic Biology" and "Encoding Collective Behavior"! http://www.sciencedirect.com/science/article/pii/S2405471217301850
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May 2017. Our paper entitled "A New Positive Feedback Circuit in the Fibrosis-Cancer Axis for Male Livers" was published.
April 2017: Suyen presented successfully her thesis. She was a student of Barrett the Honors College at Arizona State University. Her thesis was focused on self-organization of biliary organogenesis. Congratulations Suyen!
March, 2017: Shay defended successfully for her master thesis on GATA6 and cell fate reprogramming! Congratulations Shay!
Feb 15-17, 2017: We participated at Mayo Clinic Symposium on Regenerative Medicine and Surgery.
Feb 2017, Mo was awarded New Investigator Award from Arizona Biomedical Research Council. The award will help us to study regenerative processes in liver.
Jan 2017 , The lab was awarded "Mayo Clinic Accelerated Regenerative Medicine award" from Center for Regenerative Medicine, Mayo Clinic. This is the renewal of our 2016 award.
Oct 2016 Jeremy and Mo attend the 2016 Symposium on Organoids in Heidelburg, Germany, to deliver updates on their research. To learn more about the event see this link: http://www.embo-embl-symposia.org/symposia/2016/EES16-07/
Sep 2016 ASU Academic Calendar begins as Mo begins his class: BME 494: Molecular Medicine
Sep 2016 Ryan LeGraw joins the Ebrahimkhani lab and PhD program. Ryan has researched at Northwestern University as well as the Massachusetts General Hospital
Aug 2016 Farzaneh begins her PhD program in the School of Biological and Health Systems Engineering after researching at Oklahoma State University
March 2016 Mo co-chairs the tissue engineering session at Keystone Symposium for Stem Cells and Regeneration in Digestive Organs
March 2016 Shay has decided to tackle a master thesis on dynamics of stem cells! She has been working at ASU Mars Space Flight Facility
Feb 2016 & March 2016 Mo gives talks at Keystone Symposiums in tissue fibrosis and stromal cells in immunity as well as Stem cells and regeneration in digestive organs
Feb 2016 Mo discussed the lab research program at ASU Biological Engineering Seminar Series
Jan 2016 , The lab was awarded " Mayo Clinic Accelerated Regenerative Medicine award" from Center for Regenerative Medicine, Mayo Clinic.
Jan 2016 Our paper published in Nature Communication!
http://www.nature.com/ncomms/2016/160106/ncomms10243/full/ncomms10243.html
http://www.nature.com/ncomms/2016/160106/ncomms10243/full/ncomms10243.html
Jan 2016 Jeremy started his PhD in the School of Biological and Health Systems Engineering to investigate liver organoids. He joins us from MIT.
Jan 2016 Sharanya joined the lab as postdoctoral research assistant. Sharanya is coming from University of Houston, center for nuclear receptors and cell signalings where she studied zebrafish liver.